8YRH

Complex of SARS-CoV-2 main protease and Rosmarinic acid

Summary for 8YRH

• Entry DOI: 10.2210/pdb8yrh/pdb
• Descriptor: 3C-like proteinase nsp5, (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid (3 entities in total)
• Functional Keywords: sars-cov-2, main protease, rosmarinic acid, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 2
• Total formula weight: 66397.78

Authors

Wang, Q.S.,Li, Q.H. (deposition date: 2024-03-21, release date: 2024-07-03)

• Primary citation: Li, Q.,Zhou, X.,Wang, W.,Xu, Q.,Wang, Q.,Li, J.; Structural basis of rosmarinic acid inhibitory mechanism on SARS-CoV-2 main protease.; Biochem.Biophys.Res.Commun., 724:150230-150230, 2024; PubMed: 38865813; DOI: 10.1016/j.bbrc.2024.150230

Experimental method

X-RAY DIFFRACTION (1.841 Å)