8YPK
mouse proteasome 20S subunit in complex with compound 1
This is a non-PDB format compatible entry.
Summary for 8YPK
Entry DOI | 10.2210/pdb8ypk/pdb |
EMDB information | 39482 |
Descriptor | Proteasome subunit beta type-6, Proteasome subunit alpha type-5, Proteasome subunit alpha type-4, ... (15 entities in total) |
Functional Keywords | inhibitor, complex, proteasome, hydrolase |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 28 |
Total formula weight | 734353.68 |
Authors | |
Primary citation | Arai, Y.,Shitama, H.,Yamagishi, M.,Ono, S.,Kashima, A.,Hiraizumi, M.,Tsuda, N.,Katayama, K.,Tanaka, K.,Koda, Y.,Kato, S.,Sakata, K.,Nureki, O.,Miyazaki, H. Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 ( beta 5i)/LMP2 ( beta 1i) dual inhibitor. Bioorg.Med.Chem., 109:117790-117790, 2024 Cited by PubMed: 38906067DOI: 10.1016/j.bmc.2024.117790 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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