8YPK

mouse proteasome 20S subunit in complex with compound 1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005839	cellular_component	proteasome core complex
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005839	cellular_component	proteasome core complex
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005839	cellular_component	proteasome core complex
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005839	cellular_component	proteasome core complex
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005839	cellular_component	proteasome core complex
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005839	cellular_component	proteasome core complex
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0001530	molecular_function	lipopolysaccharide binding
G	0002376	biological_process	immune system process
G	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0042802	molecular_function	identical protein binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0000932	cellular_component	P-body
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0005840	cellular_component	ribosome
K	0005929	cellular_component	cilium
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0007519	biological_process	skeletal muscle tissue development
K	0016363	cellular_component	nuclear matrix
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0030016	cellular_component	myofibril
K	0030017	cellular_component	sarcomere
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0050727	biological_process	regulation of inflammatory response
K	0051059	molecular_function	NF-kappaB binding
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0001530	molecular_function	lipopolysaccharide binding
L	0002376	biological_process	immune system process
L	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0042802	molecular_function	identical protein binding
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043231	cellular_component	intracellular membrane-bounded organelle
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0009615	biological_process	response to virus
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0000932	cellular_component	P-body
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0005840	cellular_component	ribosome
R	0005929	cellular_component	cilium
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0007519	biological_process	skeletal muscle tissue development
R	0016363	cellular_component	nuclear matrix
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030016	cellular_component	myofibril
R	0030017	cellular_component	sarcomere
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0050727	biological_process	regulation of inflammatory response
R	0051059	molecular_function	NF-kappaB binding
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0019774	cellular_component	proteasome core complex, beta-subunit complex
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0010498	biological_process	proteasomal protein catabolic process
T	0019774	cellular_component	proteasome core complex, beta-subunit complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0004175	molecular_function	endopeptidase activity
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0019774	cellular_component	proteasome core complex, beta-subunit complex
U	0030163	biological_process	protein catabolic process
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0001530	molecular_function	lipopolysaccharide binding
W	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0036064	cellular_component	ciliary basal body
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0030163	biological_process	protein catabolic process
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0000502	cellular_component	proteasome complex
Z	0000932	cellular_component	P-body
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0043231	cellular_component	intracellular membrane-bounded organelle
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0000502	cellular_component	proteasome complex
a	0001530	molecular_function	lipopolysaccharide binding
a	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0005739	cellular_component	mitochondrion
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0036064	cellular_component	ciliary basal body
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0000932	cellular_component	P-body
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0009615	biological_process	response to virus
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGHlfQVEYAqeA

Chain	Residue	Details
N	TYR3-ALA25
J	TYR7-ALA29
R	PHE9-ALA31
H	TYR8-ALA30
P	TYR5-ALA27
O	TYR5-ALA27
L	TYR6-ALA28

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVqFngGVVLGADsrtttgsyianrvtd.KltpihdhifccrsGsaAD

Chain	Residue	Details
A	MET5-ASP52
U	MET11-ASP58
T	ILE5-ASP52
X	LEU13-ASP60
W	LEU12-ASP59
B	ALA4-ASP51
D	LEU5-ASP52
O	LEU35-ASP82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P28074

Chain	Residue	Details
D	THR2
C	THR2
R	SER64
K	SER17
K	SER63
K	SER64

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
D	ALA50
C	ALA50
S	SER134
X	SER34
X	SER40
X	SER134

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
L	SER177
G	SER177
Q	LYS205
Q	LYS229
b	SER13
b	SER15

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:22556278

Chain	Residue	Details
L	SER110
G	SER110

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P25786

Chain	Residue	Details
L	LYS115
Q	SER249
L	LYS208
G	LYS115
G	LYS208

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18034455

Chain	Residue	Details
P	TYR75
b	TYR75

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
P	TYR120
b	TYR120

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
P	LYS170
b	LYS170

---