8YN4

Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq

Summary for 8YN4

• Entry DOI: 10.2210/pdb8yn4/pdb
• EMDB information: 39414
• Descriptor: Engineered guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 5
• Total formula weight: 167129.16

Authors

Zhang, X.,Liu, G.,Li, X.,Gong, W. (deposition date: 2024-03-10, release date: 2024-10-09)

• Primary citation: Zhang, X.,Liu, G.,Zhong, Y.N.,Zhang, R.,Yang, C.C.,Niu, C.,Pu, X.,Sun, J.,Zhang, T.,Yang, L.,Zhang, C.,Li, X.,Shen, X.,Xiao, P.,Sun, J.P.,Gong, W.; Structural basis of ligand recognition and activation of the histamine receptor family; Nat Commun, 15:8296-, 2024; DOI: 10.1038/s41467-024-52585-y

Experimental method

ELECTRON MICROSCOPY (2.97 Å)