8YD2

CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib

Summary for 8YD2

• Entry DOI: 10.2210/pdb8yd2/pdb
• EMDB information: 39163
• Descriptor: ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE (3 entities in total)
• Functional Keywords: mycobacterium tuberculosis, caseinolytic protease system, activation, hydrolase
• Biological source: Mycobacterium tuberculosis H37Rv; More
• Total number of polymer chains: 14
• Total formula weight: 279539.13

Authors

Zhou, B.,Gao, Y.,Zhao, H.,Chen, W.,He, J.,Zhang, T.,Xiong, X. (deposition date: 2024-02-19, release date: 2025-03-19, Last modification date: 2026-04-01)

• Primary citation: Zhou, B.,Gao, Y.,Zhao, H.,Liu, B.,Zhang, H.,Fang, C.,Yuan, H.,Wang, J.,Li, Z.,Zhao, Y.,Huang, X.,Wang, X.,Oliveira, A.S.F.,Spencer, J.,Mulholland, A.J.,Burston, S.G.,Hu, J.,Su, N.,Chen, X.,He, J.,Zhang, T.,Xiong, X.; Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis; Nat Commun, 16:3466-, 2025; DOI: 10.1038/s41467-025-58410-4

Experimental method

ELECTRON MICROSCOPY (2.39 Å)