8YD2
CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib
Functional Information from PROSITE/UniProt
| site_id | PS00381 |
| Number of Residues | 12 |
| Details | CLP_PROTEASE_SER Endopeptidase Clp serine active site. TvcLGqAASAAA |
| Chain | Residue | Details |
| B | THR102-ALA113 |
| site_id | PS00382 |
| Number of Residues | 14 |
| Details | CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyalPharILMHQP |
| Chain | Residue | Details |
| A | ARG112-PRO125 | |
| B | ARG124-PRO137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00444 |
| Chain | Residue | Details |
| B | SER110 | |
| D | SER110 | |
| F | SER110 | |
| H | SER110 | |
| J | SER110 | |
| L | SER110 | |
| N | SER110 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00444 |
| Chain | Residue | Details |
| B | HIS135 | |
| D | HIS135 | |
| F | HIS135 | |
| H | HIS135 | |
| J | HIS135 | |
| L | HIS135 | |
| N | HIS135 |
