8Y7E

Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U12 snRNP part

Summary for 8Y7E

• Entry DOI: 10.2210/pdb8y7e/pdb
• EMDB information: 39013
• Descriptor: pre-mRNA, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein-associated proteins B and B', ... (18 entities in total)
• Functional Keywords: spliceosome, minor spliceosome, u11 snrnp, u12 snrnp, u4atac, u6atac, cenatac, txnl4b, u11 snrna, minor tri-snrnp, u12-type intron, splicing/rna, splicing-rna complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 17
• Total formula weight: 722538.24

Authors

Bai, R.,Yuan, M.,Zhang, P.,Luo, T.,Shi, Y.,Wan, R. (deposition date: 2024-02-04, release date: 2024-03-13, Last modification date: 2024-03-27)

• Primary citation: Bai, R.,Yuan, M.,Zhang, P.,Luo, T.,Shi, Y.,Wan, R.; Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.; Science, 383:1245-1252, 2024; PubMed: 38484052; DOI: 10.1126/science.adn7272

Experimental method

ELECTRON MICROSCOPY (4.66 Å)