8Y73

positive allosteric modulator(MPAM-15)-bound mu-opioid receptor-Gi complex

Summary for 8Y73

Entry DOI	10.2210/pdb8y73/pdb
EMDB information	39011
Related PRD ID	PRD_002308
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
Functional Keywords	positive allosteric modulator, mpam-15, mu-opioid receptor, allosteric agonism, allosteric opioid analgesics, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	160655.50
Authors	Luo, P.,Xu, Y.,Wang, Y.,Zhuang, Y.,Xu, H.E. (deposition date: 2024-02-03, release date: 2025-08-06)
Primary citation	Luo, P.,Xu, Y.,Wang, Y.,Zhuang, Y.,Xu, H.E. Structure based design of a positive allosteric modulator of mu-opioid receptor for synergistic analgesia To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation