8Y72

positive allosteric modulator(BMS986122)-bound mu-opioid receptor-Gi complex

Summary for 8Y72

• Entry DOI: 10.2210/pdb8y72/pdb
• EMDB information: 39010
• Related PRD ID: PRD_002308
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
• Functional Keywords: positive allosteric modulator, bms986122, mu-opioid receptor, allosteric agonism, allosteric opioid analgesics, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 160653.33

Authors

Luo, P.,Xu, Y.,Wang, Y.,Zhuang, Y.,Xu, H.E. (deposition date: 2024-02-03, release date: 2025-08-06)

• Primary citation: Luo, P.,Xu, Y.,Wang, Y.,Zhuang, Y.,Xu, H.E.; Structure based design of a positive allosteric modulator of mu-opioid receptor for synergistic analgesia; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.65 Å)