8Y66

Cryo-EM structure of human urate transporter GLUT9 bound to inhibitor apigenin

Summary for 8Y66

• Entry DOI: 10.2210/pdb8y66/pdb
• EMDB information: 38968
• Descriptor: Solute carrier family 2, facilitated glucose transporter member 9, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (2 entities in total)
• Functional Keywords: glut9, inhibitor, apigenin, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 63485.33

Authors

Pan, X.J.,Shen, Z.L.,Xu, L.,Huang, G.X.Y. (deposition date: 2024-02-01, release date: 2024-06-19)

• Primary citation: Shen, Z.,Xu, L.,Wu, T.,Wang, H.,Wang, Q.,Ge, X.,Kong, F.,Huang, G.,Pan, X.; Structural basis for urate recognition and apigenin inhibition of human GLUT9.; Nat Commun, 15:5039-5039, 2024; PubMed: 38866775; DOI: 10.1038/s41467-024-49420-9

Experimental method

ELECTRON MICROSCOPY (3.28 Å)