8Y66

Cryo-EM structure of human urate transporter GLUT9 bound to inhibitor apigenin

8Y66 の概要

• エントリーDOI: 10.2210/pdb8y66/pdb
• EMDBエントリー: 38968
• 分子名称: Solute carrier family 2, facilitated glucose transporter member 9, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (2 entities in total)
• 機能のキーワード: glut9, inhibitor, apigenin, transport protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63485.33

構造登録者

Pan, X.J.,Shen, Z.L.,Xu, L.,Huang, G.X.Y. (登録日: 2024-02-01, 公開日: 2024-06-19)

• 主引用文献: Shen, Z.,Xu, L.,Wu, T.,Wang, H.,Wang, Q.,Ge, X.,Kong, F.,Huang, G.,Pan, X.; Structural basis for urate recognition and apigenin inhibition of human GLUT9.; Nat Commun, 15:5039-5039, 2024; PubMed: 38866775; DOI: 10.1038/s41467-024-49420-9

実験手法

ELECTRON MICROSCOPY (3.28 Å)