8Y59

Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (S)-hydroxyl-acepromazine.

This is a non-PDB format compatible entry.

Summary for 8Y59

• Entry DOI: 10.2210/pdb8y59/pdb
• Related: 8Y58 8Y5B
• Descriptor: E3 ubiquitin-protein ligase TRIM21, (1~{S})-1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanol (3 entities in total)
• Functional Keywords: trim21, pryspry, (s)-hydroxyl-acepromazine, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 21925.70

Authors

Lu, P.,Cheng, Y.,Xue, L.,Ren, X.,Huang, N.,Han, T. (deposition date: 2024-01-31, release date: 2024-10-09)

• Primary citation: Lu, P.,Cheng, Y.,Xue, L.,Ren, X.,Chen, C.,Li, J.,Wu, Q.,Sun, S.,Hou, J.,Jia, W.,Li, C.,Qi, X.,Huang, N.,Han, T.; Selective degradation of multimeric proteins via chemically induced proximity to TRIM21.; To be published,

Experimental method

X-RAY DIFFRACTION (1.89 Å)