8XWW

Crystal structure of the catalytic domain of human PDE5A complexed with 2-(3-chlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid

This is a non-PDB format compatible entry.

Summary for 8XWW

• Entry DOI: 10.2210/pdb8xww/pdb
• Descriptor: Isoform PDE5A1 of cGMP-specific 3',5'-cyclic phosphodiesterase, 2-[(3-chlorophenyl)methyl]-4-oxidanylidene-3~{H}-quinazoline-7-carboxylic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40670.68

Authors

Zhang, F.C.,Huang, Y.Y.,Luo, H.B.,Wu, Y.Y. (deposition date: 2024-01-16, release date: 2025-01-22)

• Primary citation: Zhang, F.C.,Huang, Y.Y.,Luo, H.B.,Wu, Y.Y.; Discovery of Highly Potent and Selective PDE5 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.46 Å)