8XWC

Crystal structure of human 8-oxoguanine glycosylase K249H mutant bound to the substrate 8-oxoguanine DNA at pH 8.0 under 277 K

Summary for 8XWC

• Entry DOI: 10.2210/pdb8xwc/pdb
• Descriptor: DNA (5'-D(*AP*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), N-glycosylase/DNA lyase, ... (8 entities in total)
• Functional Keywords: dna, repair, lyase, dna-hydrolase complex, dna/hydrolase
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 47640.50

Authors

Unno, M.,Koga, M.,Minowa, N.,Komuro, S.,Tanaka, Y. (deposition date: 2024-01-16, release date: 2025-07-23)

• Primary citation: Unno, M.,Morikawa, M.,Sychovsky, V.,Koga, M.,Minowa, N.,Komuro, S.,Fukuta, M.,Tshuyuguchi, F.,Inamura, R.,Mano, H.,Nakashima, K.,Okamoto, Y.,Saito, T.,Hattori, Y.,Tanaka, Y.; Active residue mutation of hOGG1 provides a novel active mutant with an alternative reaction pathway; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)