8XVN

Short-chain dehydrogenase/reductase6 (SDR6) from Antrodia camphorata

Summary for 8XVN

• Entry DOI: 10.2210/pdb8xvn/pdb
• Descriptor: Short-chain dehydrogenases/reductase (2 entities in total)
• Functional Keywords: short-chain dehydrogenase/reductase, oxidoreductase
• Biological source: Taiwanofungus camphoratus
• Total number of polymer chains: 8
• Total formula weight: 227590.11

Authors

Zhang, Y.Q.,Zhang, M.,Ye, M. (deposition date: 2024-01-15, release date: 2025-01-15, Last modification date: 2026-07-29)

Primary citation

Zhang, Y.Q.,Zhang, M.,Wang, Z.L.,Bao, Y.O.,Wang, Y.Q.,Tian, Y.G.,Ye, L.,Ye, M.
[Not Available].
Angew.Chem.Int.Ed.Engl., 64:e202420104-e202420104, 2025

PubMed Abstract: Through different gene mining strategies, three key enzymes (AcCYP4, AcSDR6, AcSMT1) involved in the downstream biosynthesis of major lanostane-type triterpenoids were discovered and identified from Antrodia camphorata. The catalytic mechanisms of AcSDR6 were elucidated by crystal structure analysis. These post-modification enzymes could be used to synthesize at least 11 major Antrodia lanostanoids.

PubMed: 39617723
DOI: 10.1002/anie.202420104

Experimental method

X-RAY DIFFRACTION (2 Å)