8XVH

Cryo-EM structure of ETBR bound with Endothelin1

Summary for 8XVH

• Entry DOI: 10.2210/pdb8xvh/pdb
• EMDB information: 38704
• Descriptor: Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, complex, etb, endothelin-1, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 190050.11

Authors

Hou, J.Y.,Liu, S.H.,Wu, L.J.,Liu, Z.J.,Hua, T. (deposition date: 2024-01-15, release date: 2024-08-28)

• Primary citation: Hou, J.,Liu, S.,Zhang, X.,Tu, G.,Wu, L.,Zhang, Y.,Yang, H.,Li, X.,Liu, J.,Jiang, L.,Tan, Q.,Bai, F.,Liu, Z.,Miao, C.,Hua, T.,Luo, Z.; Structural basis of antagonist selectivity in endothelin receptors.; Cell Discov, 10:79-79, 2024; PubMed: 39075075; DOI: 10.1038/s41421-024-00705-9

Experimental method

ELECTRON MICROSCOPY (3.26 Å)