8XRP

The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex

Summary for 8XRP

• Entry DOI: 10.2210/pdb8xrp/pdb
• EMDB information: 38609
• Descriptor: Interleukin-12 subunit alpha, Interleukin-12 subunit beta, Interleukin-12 receptor subunit beta-2, ... (6 entities in total)
• Functional Keywords: il-12, il-12rb1, il-12rb2, receptor complex, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 476826.49

Authors

Chen, H.Q.,Wang, X.Q.,Ge, X.F.,Zeng, J.W.,Wang, J.W. (deposition date: 2024-01-07, release date: 2024-07-24, Last modification date: 2024-08-21)

• Primary citation: Chen, H.,Ge, X.,Li, C.,Zeng, J.,Wang, X.; Structure and assembly of the human IL-12 signaling complex.; Structure, 2024; PubMed: 39111304; DOI: 10.1016/j.str.2024.07.010

Experimental method

ELECTRON MICROSCOPY (3.75 Å)