8XLO
FGFR1 kinase domain with a dual-warhead covalent inhibitor CXF-007
This is a non-PDB format compatible entry.
Summary for 8XLO
Entry DOI | 10.2210/pdb8xlo/pdb |
Descriptor | Fibroblast growth factor receptor 1, CXF007, SULFATE ION, ... (4 entities in total) |
Functional Keywords | fibroblast growth factor receptor 1, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 72344.76 |
Authors | |
Primary citation | Chen, X.,Li, H.,Lin, Q.,Dai, S.,Qu, L.,Guo, M.,Zhang, L.,Liao, J.,Wei, H.,Xu, G.,Jiang, L.,Chen, Y. Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4. Eur.J.Med.Chem., 268:116281-116281, 2024 Cited by PubMed: 38432058DOI: 10.1016/j.ejmech.2024.116281 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
Download full validation report