8XJU

Cryo-EM structure of colibactin assembly line polyketide synthase ClbI (apo state)

Summary for 8XJU

Entry DOI	10.2210/pdb8xju/pdb
EMDB information	38406
Descriptor	Polyketide synthase (1 entity in total)
Functional Keywords	colibactin, microbiome, polyketide synthase, colorectal cancer, nrps-pks hybrid, biosynthetic protein, transferase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	221305.48
Authors	Kim, M.,Kim, J.,Kang, J.Y. (deposition date: 2023-12-22, release date: 2025-05-21)
Primary citation	Kim, M.,Kim, J.,Olinares, P.D.B.,Park, J.,Chait, B.T.,Kang, J.Y. Cryo-EM structures of human microbiome-derived polyketide synthases that assemble genotoxic colibactin Structure, 33:1-16, 2025 Cited by DOI: 10.1016/j.str.2025.04.017 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.91 Å)

Structure validation