8XF4

Structure of the siderophore periplasmic binding protein FtsB from Streptococcus pyogenes with Bisucaberin bound

Summary for 8XF4

• Entry DOI: 10.2210/pdb8xf4/pdb
• Descriptor: Iron-hydroxamate ABC transporter substrate-binding protein FtsB, 1,12-bis(oxidanyl)-1,6,12,17-tetrazacyclodocosane-2,5,13,16-tetrone, FE (III) ION, ... (4 entities in total)
• Functional Keywords: streptococcus pyogenes, siderophore, hydroxamate, ftsb, abc transporter, alanine scanning, antibiotic strategy, bisucaberin, metal binding protein
• Biological source: Streptococcus pyogenes SSI-1
• Total number of polymer chains: 1
• Total formula weight: 32762.11

Authors

Caaveiro, J.M.M.,Fernandez-Perez, J.,Tsumoto, K. (deposition date: 2023-12-13, release date: 2024-10-09)

• Primary citation: Fernandez-Perez, J.,Caaveiro, J.M.M.,Senoo, A.,Nakakido, M.,De Vega, S.,Nakagawa, I.,Tsumoto, K.; Conserved binding mechanism for ligand promiscuity in the hydroxamate siderophore binding protein FtsB from Streptococcus pyogenes; Structure, ; DOI: 10.1016/j.str.2024.09.018

Experimental method

X-RAY DIFFRACTION (2 Å)