8XBL

Cryo-EM structure of colibactin assembly line polyketide synthase ClbC (apo state)

Summary for 8XBL

• Entry DOI: 10.2210/pdb8xbl/pdb
• EMDB information: 38222
• Descriptor: Colibactin polyketide synthase ClbC (1 entity in total)
• Functional Keywords: colibactin, microbiome, polyketide synthase, colorectal cancer, nrps-pks hybrid, biosynthetic protein
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 198605.92

Authors

Kim, J.,Kim, M.,Kang, J.Y. (deposition date: 2023-12-06, release date: 2025-05-21)

• Primary citation: Kim, M.,Kim, J.,Olinares, P.D.B.,Park, J.,Chait, B.T.,Kang, J.Y.; Cryo-EM structures of human microbiome-derived polyketide synthases that assemble genotoxic colibactin; Structure, 33:1-16, 2025; DOI: 10.1016/j.str.2025.04.017

Experimental method

ELECTRON MICROSCOPY (3.06 Å)