8X7H

Crystal structure of the ternary complex of GID4-PROTAC(NEP162)-BRD4(BD1).

Summary for 8X7H

Entry DOI	10.2210/pdb8x7h/pdb
Descriptor	Glucose-induced degradation protein 4 homolog, Bromodomain-containing protein 4, ~{N}-[4-[6-[3-[4-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoyl]piperazin-1-yl]propoxy]-1~{H}-benzimidazol-2-yl]cyclohexyl]-2-(1~{H}-indol-2-ylmethylamino)ethanamide, ... (5 entities in total)
Functional Keywords	ubiquitin ligase, cytosolic protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	142614.76
Authors	Dong, C.,Yan, X.,Li, Y. (deposition date: 2023-11-24, release date: 2025-03-26)
Primary citation	Dong, C.,Yan, X.,Li, Y. Crystal structure of 162 To Be Published,
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation