8X6R
KRasG12C in complex with inhibitor
Summary for 8X6R
Entry DOI | 10.2210/pdb8x6r/pdb |
Descriptor | Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | gtp-binding, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 122700.78 |
Authors | |
Primary citation | Imaizumi, T.,Shimada, I.,Satake, Y.,Yamaki, S.,Koike, T.,Nigawara, T.,Kaneko, O.,Amano, Y.,Mori, K.,Yamanaka, Y.,Nakayama, A.,Nishizono, Y.,Shimazaki, M.,Nagashima, T.,Kuramoto, K. Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors. Bioorg.Med.Chem., 98:117581-117581, 2023 Cited by PubMed: 38176113DOI: 10.1016/j.bmc.2023.117581 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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