8X21

HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/L74V:DNA:ETV-TP ternary complex

Summary for 8X21

• Entry DOI: 10.2210/pdb8x21/pdb
• Descriptor: Pol protein (Fragment), HIV-1 RT p51 subunit, DNA/RNA (38-MER), ... (7 entities in total)
• Functional Keywords: reverse transcriptase, hiv-1, hbv, drug resistance, nucleoside analogue, entecavir, transferase
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 256846.44

Authors

Yasutake, Y.,Hattori, S.I.,Mitsuya, H. (deposition date: 2023-11-09, release date: 2024-07-17)

• Primary citation: Yasutake, Y.,Hattori, S.I.,Kumamoto, H.,Tamura, N.,Maeda, K.,Mitsuya, H.; Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations.; Sci Rep, 14:15742-15742, 2024; PubMed: 38977798; DOI: 10.1038/s41598-024-66505-z

Experimental method