8WZZ

Short-chain dehydrogenase/reductase16 (SDR16) from Antrodia camphorata

Summary for 8WZZ

Entry DOI	10.2210/pdb8wzz/pdb
Descriptor	SDR16 (2 entities in total)
Functional Keywords	short-chain dehydrogenase/reductase, oxidoreductase
Biological source	Taiwanofungus camphoratus
Total number of polymer chains	1
Total formula weight	32893.36
Authors	Zhang, Y.Q.,Zhang, M.,Ye, M. (deposition date: 2023-11-02, release date: 2024-11-06, Last modification date: 2025-05-21)
Primary citation	Zhang, Y.Q.,Zhang, M.,Wang, Z.L.,Bao, Y.O.,Wang, Y.Q.,Tian, Y.G.,Ye, L.,Ye, M. Identification of Key Post‐modification Enzymes Involved in the Biosynthesis of Lanostane‐type Triterpenoids in the Medicinal Mushroom Antrodia camphorata Angew.Chem.Int.Ed.Engl., 64:e202420104-e202420104, 2025 Cited by PubMed Abstract: Through different gene mining strategies, three key enzymes (AcCYP4, AcSDR6, AcSMT1) involved in the downstream biosynthesis of major lanostane-type triterpenoids were discovered and identified from Antrodia camphorata. The catalytic mechanisms of AcSDR6 were elucidated by crystal structure analysis. These post-modification enzymes could be used to synthesize at least 11 major Antrodia lanostanoids. PubMed: 39617723 DOI: 10.1002/anie.202420104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation