8WU5

The complex of CAG repeat sequence-specific binding cPIP and dsDNA with A-A mismatch

This is a non-PDB format compatible entry.

Summary for 8WU5

• Entry DOI: 10.2210/pdb8wu5/pdb
• Descriptor: DNA (5'-D(*GP*CP*(CBR)P*GP*AP*GP*CP*AP*GP*CP*AP*CP*GP*GP*C)-3'), (1^2Z,4^2Z,11^2Z,14^2Z,22^2Z,25^2Z,32^2Z,35^2Z,19R,40R)-1^1,4^1,11^1,14^1,22^1,25^1,32^1,35^1-octamethyl-2,5,9,12,15,20,23,26,30,33,36,41-dodecaoxo-1^1H,4^1H,11^1H,14^1H,22^1H,25^1H,32^1H,35^1H-3,6,10,13,16,21,24,27,31,34,37,42-dodecaaza-1(2,4),11,22,32(4,2)-tetraimidazola-4,14,25,35(4,2)-tetrapyrrolacyclodotetracontaphane-19,40-diaminium (2 entities in total)
• Functional Keywords: dna minor groove binder pyrrole imidazole polyamide a-a mismatch dna cag repeat, dna
• Biological source: synthetic construct
• Total number of polymer chains: 4
• Total formula weight: 21382.22

Authors

Abe, K.,Takeda, K.,Sugiyama, H. (deposition date: 2023-10-20, release date: 2024-06-05, Last modification date: 2024-06-12)

• Primary citation: Abe, K.,Hirose, Y.,Kumagai, T.,Hashiya, K.,Hidaka, K.,Emura, T.,Bando, T.,Takeda, K.,Sugiyama, H.; Structural Studies of a Complex of a CAG/CTG Repeat Sequence-Specific Binding Molecule and A-A-Mismatch-Containing DNA.; Jacs Au, 4:1801-1810, 2024; PubMed: 38818057; DOI: 10.1021/jacsau.3c00830

Experimental method

X-RAY DIFFRACTION (2.8 Å)