8WRY

Cryo-EM Structure of Mouse TLR4/MD-2/DLAM3 Complex

Summary for 8WRY

• Entry DOI: 10.2210/pdb8wry/pdb
• Related: 8WO1 8WQT 8WSA 8WTA 9J03
• EMDB information: 37794
• Descriptor: Lymphocyte antigen 96, Toll-like receptor 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: innate immune system, toll-like receptors, tlr4 agonist, vaccine adjuvants, disaccharide-based lipid a mimetics, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 179722.43

Authors

Fu, Y.,Kim, H.,Zamyatina, A.,Kim, H.M. (deposition date: 2023-10-16, release date: 2024-10-23, Last modification date: 2025-03-19)

• Primary citation: Fu, Y.,Kim, H.; Structural insight on tailored modulation of TLR4-mediated pro-inflammatory response by disaccharide lipid A mimetics; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)