8WPW

Cryo-EM structure of SARS-CoV-2 XBB.1.5 receptor-binding domain (RBD) complexed with CB6 mutant,S309, and S304 antibodies

Summary for 8WPW

• Entry DOI: 10.2210/pdb8wpw/pdb
• EMDB information: 37725
• Descriptor: S309 fab heavy chain, S309 fab light chain, CB6 fab mutant heavy chain, ... (8 entities in total)
• Functional Keywords: sars-cov-2, xbb.1.5, rbd, cb6, receptor-binding domain, etesevimab, mutant, viral protein, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 7
• Total formula weight: 172408.15

Authors

Su, C.,Qi, J.X.,Gao, G.F. (deposition date: 2023-10-10, release date: 2024-10-16, Last modification date: 2025-10-29)

• Primary citation: Su, C.,He, J.,Xie, Y.,Hu, Y.,Li, X.,Qiao, S.,Liu, P.,Huang, M.,Zhang, R.,Wang, L.,Chang, Z.,Sun, W.,Xu, K.,Zhang, J.,Cao, L.,Han, P.,Zhao, X.,Qi, J.,Wang, Q.,Yang, M.,Gao, G.F.; Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2; Hlife, 3:132-145, 2025

Experimental method

ELECTRON MICROSCOPY (2.49 Å)