8WPG

Human calcium-sensing receptor bound with cinacalcet in detergent

8WPG の概要

• エントリーDOI: 10.2210/pdb8wpg/pdb
• EMDBエントリー: 37716
• 分子名称: Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: gpcr, allosteric modulator, activation, dimeric, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 208360.58

構造登録者

Ling, S.L.,Meng, X.Y.,Tian, C.L. (登録日: 2023-10-10, 公開日: 2023-11-22, 最終更新日: 2024-02-21)

• 主引用文献: Ling, S.,Meng, X.,Zhang, Y.,Xia, Z.,Zhou, Y.,Yang, F.,Shi, P.,Shi, C.,Tian, C.; Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.; Cell Res., 34:169-172, 2024; PubMed: 37919470; DOI: 10.1038/s41422-023-00892-2

実験手法

ELECTRON MICROSCOPY (2.7 Å)