8WMO

Crystal structure analysis of tubulin and heterocyclic podophyllotoxins complex for anticancer agents

Summary for 8WMO

• Entry DOI: 10.2210/pdb8wmo/pdb
• Descriptor: Detyrosinated tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (5~{S},5~{a}~{R},8~{a}~{R},9~{R})-5-pyrimidin-2-ylsulfanyl-9-(3,4,5-trimethoxyphenyl)-5~{a},6,8~{a},9-tetrahydro-5~{H}-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one, ... (14 entities in total)
• Functional Keywords: tubulin, heterocyclic podophyllotoxins complex, anticancer agents, cell cycle
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 262140.70

Authors

Zhao, W.,Bi, J. (deposition date: 2023-10-04, release date: 2024-10-09)

• Primary citation: Zhao, W.; Crystal structure analysis of tubulin and heterocyclic podophyllotoxins complex for anticancer agents; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.89 Å)