8WKY

Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25

Summary for 8WKY

• Entry DOI: 10.2210/pdb8wky/pdb
• Descriptor: Melanocortin receptor 4, N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: ca++ cofactor, gpcr, pgs fusion, membrane protein, lcp
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 63026.48

Authors

Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.,Dahir, N.S.,Wu, Y.,Yao, D.,Han, G.W.,Wu, L.,Poorten, O.V.,Lamouroux, A.,Mannes, M.,Tourwe, D.,Zhao, S.,Stevens, R.C.,Cone, R.D.,Ballet, S. (deposition date: 2023-09-28, release date: 2024-08-07)

• Primary citation: Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.C.,Wu, Y.,Yao, D.,Han, G.W.,Dahir, N.S.,Wu, L.,Van der Poorten, O.,Lamouroux, A.,Mannes, M.,Zhao, S.,Tourwe, D.,Stevens, R.C.,Cone, R.D.,Ballet, S.; Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.; J.Med.Chem., 67:2690-2711, 2024; PubMed: 38345933; DOI: 10.1021/acs.jmedchem.3c01822

Experimental method