8WKG

Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

8WKG の概要

• エントリーDOI: 10.2210/pdb8wkg/pdb
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase, (~{E})-3-[2-[(3-chlorophenyl)methyl]-4-oxidanylidene-3~{H}-quinazolin-7-yl]prop-2-enoic acid, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38908.70

構造登録者

Zhang, F.C.,Huang, Y.Y. (登録日: 2023-09-27, 公開日: 2024-10-02)

• 主引用文献: Zhang, F.C.,Huang, Y.Y.,Luo, H.B.,Wu, Y.N.; Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis; To Be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)