8WFP

Crystal structure of polo-like kinase(PLK1)PBD in complex with DD-1

Summary for 8WFP

• Entry DOI: 10.2210/pdb8wfp/pdb
• Descriptor: Serine/threonine-protein kinase PLK1, DD-1 (3 entities in total)
• Functional Keywords: inhibitor, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 53422.76

Authors

Park, J.,La, Y.K.,Bang, J.K.,Lee, S.J. (deposition date: 2023-09-20, release date: 2024-09-25)

• Primary citation: Gunasekaran, P.,Hwang, Y.S.,Lee, G.H.,Park, J.,Kim, J.G.,La, Y.K.,Park, N.Y.,Kothandaraman, R.,Yim, M.S.,Choi, J.,Kim, H.N.,Park, I.Y.,Lee, S.J.,Kim, M.H.,Cha-Molstad, H.,Shin, S.Y.,Ryu, E.K.,Bang, J.K.; Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer.; J.Med.Chem., 67:3307-3320, 2024; PubMed: 38105611; DOI: 10.1021/acs.jmedchem.3c01493

Experimental method

X-RAY DIFFRACTION (1.99 Å)