8W7H
Purine Nucleoside Phosphorylase in complex with MMV000848
Summary for 8W7H
Entry DOI | 10.2210/pdb8w7h/pdb |
Descriptor | Purine nucleoside phosphorylase, (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | protein binding, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Plasmodium falciparum 3D7 |
Total number of polymer chains | 1 |
Total formula weight | 28302.55 |
Authors | Chung, Z.,Lin, J.Q.,Lescar, J. (deposition date: 2023-08-30, release date: 2024-01-17, Last modification date: 2024-01-31) |
Primary citation | Chung, Z.,Lin, J.,Wirjanata, G.,Dziekan, J.M.,El Sahili, A.,Preiser, P.R.,Bozdech, Z.,Lescar, J. Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848. J.Biol.Chem., 300:105586-105586, 2023 Cited by PubMed: 38141766DOI: 10.1016/j.jbc.2023.105586 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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