8W7E

Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP)

Summary for 8W7E

• Entry DOI: 10.2210/pdb8w7e/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, 3-[(3-chlorophenyl)methyl]-6-[(4-chlorophenyl)methyl]-2,4-dihydro-1H-pyrido[2,3-c][2,7]naphthyridin-5-one (2 entities in total)
• Functional Keywords: f20, activators, hclpp, apoptosis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 14
• Total formula weight: 346841.10

Authors

Jiang, J.-X.,Ding, H.,Chen, M.-R.,Lu, M.-L.,Sun, H.-Y.,Xiao, Y.-B. (deposition date: 2023-08-30, release date: 2024-09-04)

• Primary citation: Jiang, J.-X.,Ding, H.,Chen, M.-R.,Lu, M.-L.,Sun, H.-Y.,Xiao, Y.-B.; Design, synthesis and biological evaluations of novel small molecular hyper-activators of human caseinolytic peptidase P (hClpP); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)