8W4V

Crystal structure of human HSP90 in complex with compound 4

Summary for 8W4V

• Entry DOI: 10.2210/pdb8w4v/pdb
• Descriptor: Heat shock protein HSP 90-alpha, MAGNESIUM ION, 4-[2-[(dimethylamino)methyl]phenyl]sulfanylbenzene-1,3-diol, ... (4 entities in total)
• Functional Keywords: hsp90, atpase, ntd, complex, inhibitor, chaperone
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 27637.23

Authors

Xu, C.,Zhang, X.L.,Bai, F. (deposition date: 2023-08-25, release date: 2024-04-17)

• Primary citation: Xu, C.,Zhang, X.,Zhao, L.,Verkhivker, G.M.,Bai, F.; Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies; Jacs Au, 2024; DOI: 10.1021/jacsau.4c00123

Experimental method

X-RAY DIFFRACTION (1.81 Å)