8W4R
Crystal structure of PDE4D complexed with CVT-313
Summary for 8W4R
Entry DOI | 10.2210/pdb8w4r/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol), MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pde4d, complex, inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81669.63 |
Authors | |
Primary citation | Liu, J.,Zhang, X.,Chen, G.,Shao, Q.,Zou, Y.,Li, Z.,Su, H.,Li, M.,Xu, Y. Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262:115893-115893, 2023 Cited by PubMed: 37918035DOI: 10.1016/j.ejmech.2023.115893 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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