8W4M

Crystal structure of open conformation of human immunoglobulin Fc in presence of EndoSz

8W4M の概要

• エントリーDOI: 10.2210/pdb8w4m/pdb
• 関連するPDBエントリー: 8W4L
• 分子名称: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• 機能のキーワード: n-linked glycan, glycoside hydrolase, transglycosylation, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27409.08

構造登録者

Guan, H.H.,Lin, C.C.,Hsieh, Y.C.,Chen, C.J. (登録日: 2023-08-24, 公開日: 2024-07-03, 最終更新日: 2024-07-10)

• 主引用文献: Hsieh, Y.C.,Guan, H.H.,Lin, C.C.,Huang, T.Y.,Chuankhayan, P.,Chen, N.C.,Wang, N.H.,Hu, P.L.,Tsai, Y.C.,Huang, Y.C.,Yoshimura, M.,Lin, P.J.,Hsieh, Y.H.,Chen, C.J.; Structure-Based High-Efficiency Homogeneous Antibody Platform by Endoglycosidase Sz Provides Insights into Its Transglycosylation Mechanism.; Jacs Au, 4:2130-2150, 2024; PubMed: 38938812; DOI: 10.1021/jacsau.4c00004

実験手法

X-RAY DIFFRACTION (2.18 Å)