8W4E

Crystal structure of the sigma-1 receptor from Xenopus laevis in the absence of known ligands (C2 form)

Summary for 8W4E

• Entry DOI: 10.2210/pdb8w4e/pdb
• Descriptor: Sigma non-opioid intracellular receptor 1 (2 entities in total)
• Functional Keywords: sigma receptor, s1r, endogenous ligand, neurosteroid, p4, membrane protein
• Biological source: Xenopus laevis (African clawed frog)
• Total number of polymer chains: 6
• Total formula weight: 154321.93

Authors

Xiao, Y.,Fu, C.,Sun, Z.,Zhou, X. (deposition date: 2023-08-23, release date: 2024-07-17)

• Primary citation: Fu, C.,Xiao, Y.,Zhou, X.,Sun, Z.; Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.; Nat Commun, 15:5619-5619, 2024; PubMed: 38965213; DOI: 10.1038/s41467-024-49894-7

Experimental method

X-RAY DIFFRACTION (2.805 Å)