8W4E

Crystal structure of the sigma-1 receptor from Xenopus laevis in the absence of known ligands (C2 form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005640	cellular_component	nuclear outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0038023	molecular_function	signaling receptor activity
A	0043523	biological_process	regulation of neuron apoptotic process
A	1905897	biological_process	regulation of response to endoplasmic reticulum stress
B	0005635	cellular_component	nuclear envelope
B	0005637	cellular_component	nuclear inner membrane
B	0005640	cellular_component	nuclear outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0038023	molecular_function	signaling receptor activity
B	0043523	biological_process	regulation of neuron apoptotic process
B	1905897	biological_process	regulation of response to endoplasmic reticulum stress
C	0005635	cellular_component	nuclear envelope
C	0005637	cellular_component	nuclear inner membrane
C	0005640	cellular_component	nuclear outer membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0038023	molecular_function	signaling receptor activity
C	0043523	biological_process	regulation of neuron apoptotic process
C	1905897	biological_process	regulation of response to endoplasmic reticulum stress
D	0005635	cellular_component	nuclear envelope
D	0005637	cellular_component	nuclear inner membrane
D	0005640	cellular_component	nuclear outer membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0014069	cellular_component	postsynaptic density
D	0016020	cellular_component	membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0038023	molecular_function	signaling receptor activity
D	0043523	biological_process	regulation of neuron apoptotic process
D	1905897	biological_process	regulation of response to endoplasmic reticulum stress
E	0005635	cellular_component	nuclear envelope
E	0005637	cellular_component	nuclear inner membrane
E	0005640	cellular_component	nuclear outer membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0014069	cellular_component	postsynaptic density
E	0016020	cellular_component	membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0038023	molecular_function	signaling receptor activity
E	0043523	biological_process	regulation of neuron apoptotic process
E	1905897	biological_process	regulation of response to endoplasmic reticulum stress
F	0005635	cellular_component	nuclear envelope
F	0005637	cellular_component	nuclear inner membrane
F	0005640	cellular_component	nuclear outer membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0014069	cellular_component	postsynaptic density
F	0016020	cellular_component	membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0038023	molecular_function	signaling receptor activity
F	0043523	biological_process	regulation of neuron apoptotic process
F	1905897	biological_process	regulation of response to endoplasmic reticulum stress

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Region: {"description":"Important for ligand-binding","evidences":[{"source":"UniProtKB","id":"Q60492","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"Important for ligand binding","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---