8W47
X-ray crystal structure of V30M-TTR in complex with isorhapontigenin
Summary for 8W47
Entry DOI | 10.2210/pdb8w47/pdb |
Descriptor | Transthyretin, 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, SODIUM ION, ... (4 entities in total) |
Functional Keywords | amyloidogenesis, inhibitor, resveratrol, thyroid hormone, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 35247.68 |
Authors | Yokoyama, T. (deposition date: 2023-08-23, release date: 2023-11-22, Last modification date: 2023-12-06) |
Primary citation | Yokoyama, T.,Kusaka, K.,Mizuguchi, M.,Nabeshima, Y.,Fujiwara, S. Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66:15511-15523, 2023 Cited by PubMed: 37910439DOI: 10.1021/acs.jmedchem.3c01698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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