8W47

X-ray crystal structure of V30M-TTR in complex with isorhapontigenin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transthyretin	polymer	159	17342.6	2	UniProt (P02766) Pfam (PF00576)	Homo sapiens (human)	ATTR,Prealbumin,TBPA
2	C, E (A, B)	5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol	non-polymer		258.3	2	Chemie (P5O)
3	D, F (A, B)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4	G, H (A, B)	water	water		18.0	199	Chemie (HOH)

Sequence modifications

A, B: -19 - 127 (UniProt: P02766)

PDB	External Database	Details
Met -31	-	initiating methionine
Arg -30	-	expression tag
Gly -29	-	expression tag
Ser -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Met 30	Val 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34685.2
Non-Polymers*	Number of molecules	4
	Total formula weight	562.5
All*	Total formula weight	35247.7

*Water molecules are not included.