8W2F
Plasmodium falciparum 20S proteasome bound to an inhibitor
This is a non-PDB format compatible entry.
Summary for 8W2F
Entry DOI | 10.2210/pdb8w2f/pdb |
EMDB information | 43746 |
Descriptor | Proteasome endopeptidase complex, Proteasome subunit beta, Proteasome subunit beta type, ... (15 entities in total) |
Functional Keywords | malaria, plasmodium falciparum, proteasome, drug discovery, cytosolic protein, cytosolic protein-inhibitor complex, cytosolic protein/inhibitor |
Biological source | Plasmodium falciparum 3D7 More |
Total number of polymer chains | 28 |
Total formula weight | 767152.69 |
Authors | Han, Y.,Deng, X.,Ray, S.,Chen, Z.,Phillips, M. (deposition date: 2024-02-20, release date: 2024-07-31) |
Primary citation | Lawong, A.,Gahalawat, S. Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria Cell Chem Biol, 2024 |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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