8W1V

The beta2 adrenergic receptor bound to a bitopic ligand

This is a non-PDB format compatible entry.

Summary for 8W1V

• Entry DOI: 10.2210/pdb8w1v/pdb
• Descriptor: Beta-2 adrenergic receptor,Endolysin, Nanobody60, (2S)-1-[(3-{1-[4-(4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butyl]-1H-1,2,3-triazol-4-yl}propyl)amino]-3-(2-propylphenoxy)propan-2-ol, ... (4 entities in total)
• Functional Keywords: signal transduction, bitopic ligand, , signaling protein, gpcr, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 153648.52

Authors

Gaiser, B.,Danielsen, M.,Xu, X.,Jorgensen, K.,Fronik, P.,Marcher-Rorsted, E.,Wrobe, T.,Hirata, K.,Liu, X.,Mathiesen, J.,Pedersen, D. (deposition date: 2024-02-19, release date: 2024-07-17, Last modification date: 2024-07-24)

• Primary citation: Gaiser, B.I.,Danielsen, M.,Xu, X.,Ropke Jorgensen, K.,Fronik, P.,Marcher-Rorsted, E.,Wrobel, T.M.,Liu, X.,Mosolff Mathiesen, J.,Sejer Pedersen, D.; Bitopic Ligands Support the Presence of a Metastable Binding Site at the beta 2 Adrenergic Receptor.; J.Med.Chem., 67:11053-11068, 2024; PubMed: 38952152; DOI: 10.1021/acs.jmedchem.4c00578

Experimental method