8W1V
The beta2 adrenergic receptor bound to a bitopic ligand
This is a non-PDB format compatible entry.
Summary for 8W1V
Entry DOI | 10.2210/pdb8w1v/pdb |
Descriptor | Beta-2 adrenergic receptor,Endolysin, Nanobody60, (2S)-1-[(3-{1-[4-(4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butyl]-1H-1,2,3-triazol-4-yl}propyl)amino]-3-(2-propylphenoxy)propan-2-ol, ... (4 entities in total) |
Functional Keywords | signal transduction, bitopic ligand, , signaling protein, gpcr, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 153648.52 |
Authors | Gaiser, B.,Danielsen, M.,Xu, X.,Jorgensen, K.,Fronik, P.,Marcher-Rorsted, E.,Wrobe, T.,Hirata, K.,Liu, X.,Mathiesen, J.,Pedersen, D. (deposition date: 2024-02-19, release date: 2024-07-17, Last modification date: 2024-07-24) |
Primary citation | Gaiser, B.I.,Danielsen, M.,Xu, X.,Ropke Jorgensen, K.,Fronik, P.,Marcher-Rorsted, E.,Wrobel, T.M.,Liu, X.,Mosolff Mathiesen, J.,Sejer Pedersen, D. Bitopic Ligands Support the Presence of a Metastable Binding Site at the beta 2 Adrenergic Receptor. J.Med.Chem., 67:11053-11068, 2024 Cited by PubMed: 38952152DOI: 10.1021/acs.jmedchem.4c00578 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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