8W13
Crystal structure of MYST acetyltransferase domain in complex with N-(1-(5-bromo-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-2-methoxybenzenesulfonamide
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Summary for 8W13
Entry DOI | 10.2210/pdb8w13/pdb |
Descriptor | Histone acetyltransferase KAT8, N-[(1M)-1-(5-bromo-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-2-methoxybenzene-1-sulfonamide, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | acetyltransferase, kat8, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33855.99 |
Authors | Chen, C.,Dou, Y.,Wang, M.,Xu, C.,Buesking, A. (deposition date: 2024-02-15, release date: 2024-09-11, Last modification date: 2024-09-25) |
Primary citation | Chen, C.,Pawley, S.B.,Cote, J.M.,Carter, J.,Wang, M.,Xu, C.,Buesking, A.W. Identification of triazolyl KAT6 inhibitors via a templated fragment approach. Bioorg.Med.Chem.Lett., 113:129948-129948, 2024 Cited by PubMed: 39236793DOI: 10.1016/j.bmcl.2024.129948 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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