8W0Y
Crystal structure of broadly neutralizing antibody hcab17 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
Summary for 8W0Y
Entry DOI | 10.2210/pdb8w0y/pdb |
Descriptor | hcab17 Fab Heavy Chain, hcab17 Fab Light Chain, Envelope glycoprotein E2, ... (8 entities in total) |
Functional Keywords | hcv glycoprotein, broadly neutralizing antibodies, immune system, immune system-viral protein complex, immune system/viral protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 6 |
Total formula weight | 160387.11 |
Authors | Flyak, A.I.,Wilcox, X.E. (deposition date: 2024-02-14, release date: 2024-03-27, Last modification date: 2024-04-17) |
Primary citation | Ogega, C.O.,Skinner, N.E.,Schoenle, M.V.,Wilcox, X.E.,Frumento, N.,Wright, D.A.,Paul, H.T.,Sinnis-Bourozikas, A.,Clark, K.E.,Figueroa, A.,Bjorkman, P.J.,Ray, S.C.,Flyak, A.I.,Bailey, J.R. Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance. Immunity, 57:890-903.e6, 2024 Cited by PubMed: 38518779DOI: 10.1016/j.immuni.2024.03.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.31 Å) |
Structure validation
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