8W0O

GDH-105 crystal structure

Summary for 8W0O

• Entry DOI: 10.2210/pdb8w0o/pdb
• Descriptor: Dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: protein engineering, glucose dehydrogenase, scalable manufacturing, oxidoreductase
• Biological source: Bacillus subtilis
• Total number of polymer chains: 8
• Total formula weight: 230459.29

Authors

Peat, T.S.,Newman, J. (deposition date: 2024-02-13, release date: 2024-07-24)

• Primary citation: Yi, X.,Kleinbeck, F.,Ching, C.,Boghospor, L.,Gomes, S.,Alvizo, O.,Allmendinger, T.,Fell, J.,Subramanian, N.,Li, M.,Garcia, R.,Riggins, J.,Entwistle, D.,Richter, Y.,Gschwend, D.,Lauener, L.,Peat, T.S.,Lebhar, H.,Schlama, T.,Ruch, T.; Enhancing the Imine Reductase Activity of a Promiscuous Glucose Dehydrogenase for Scalable Manufacturing of a Chiral Neprilysin Inhibitor Precursor; Acs Catalysis, 14:7087-7096, 2024; DOI: 10.1021/acscatal.3c05615

Experimental method

X-RAY DIFFRACTION (1.66 Å)