8W07

Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-402

This is a non-PDB format compatible entry.

Summary for 8W07

• Entry DOI: 10.2210/pdb8w07/pdb
• Descriptor: Estrogen receptor, (1R,2S,4R)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, (1S,2R,4S)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, ... (4 entities in total)
• Functional Keywords: estrogen receptor alpha, nuclear protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 112436.16

Authors

Min, C.K.,Nwachukwu, J.C.,Hou, Y.,Russo, R.J.,Papa, A.,Min, J.,Peng, R.,Kim, S.H.,Ziegler, Y.,Rangarajan, E.S.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.K.,Nettles, K.W. (deposition date: 2024-02-13, release date: 2024-06-12)

• Primary citation: Min, C.K.,Nwachukwu, J.C.,Hou, Y.,Russo, R.J.,Papa, A.,Min, J.,Peng, R.,Kim, S.H.,Ziegler, Y.,Rangarajan, E.S.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W.; Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu.; Proc.Natl.Acad.Sci.USA, 121:e2321344121-e2321344121, 2024; PubMed: 38830107; DOI: 10.1073/pnas.2321344121

Experimental method

X-RAY DIFFRACTION (1.83 Å)