8VYM

Soluble ectodomain of human cytomegalovirus (HCMV) glycoprotein B (gB) in the postfusion conformation in complex with 1G2 and 7H3 Fabs

Summary for 8VYM

• Entry DOI: 10.2210/pdb8vym/pdb
• EMDB information: 43667
• Descriptor: Envelope glycoprotein B, 1G2 Fab Heavy Chain, 1G2 Fab Light Chain, ... (8 entities in total)
• Functional Keywords: orthoherpesvirus, betaherpesvirus, cytomegalovirus, human betaherpesvirus 5, human cytomegalovirus, hcmv, glycoprotein b, gb, hcmv gb, viral protein, 7h3, 1g2, viral protein-immune system complex, viral protein/immune system
• Biological source: Human betaherpesvirus 5; More
• Total number of polymer chains: 11
• Total formula weight: 465492.55

Authors

Sponholtz, M.R.,Byrne, P.O.,McLellan, J.S. (deposition date: 2024-02-09, release date: 2024-09-18)

• Primary citation: Sponholtz, M.R.,Byrne, P.O.,Lee, A.G.,Ramamohan, A.R.,Goldsmith, J.A.,McCool, R.S.,Zhou, L.,Johnson, N.V.,Hsieh, C.L.,Connors, M.,Karthigeyan, K.P.,Crooks, C.M.,Fuller, A.S.,Campbell, J.D.,Permar, S.R.,Maynard, J.A.,Yu, D.,Bottomley, M.J.,McLellan, J.S.; Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation.; Proc.Natl.Acad.Sci.USA, 121:e2404250121-e2404250121, 2024; PubMed: 39231203; DOI: 10.1073/pnas.2404250121

Experimental method

ELECTRON MICROSCOPY (3.4 Å)